Desyrel which contain Trazodone is an antidepressant medicine. It affects chemicals in the brain that may become unbalanced and cause depression. Trazodone is used to treat major depressive disorder. Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. Precautions:

• You should not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.


• Do not use this drug if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.


• Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or other caregivers should also be alert to changes in your mood or symptoms.


• Do not give this medication to anyone under 18 years old without medical advice.

Contraindications:To make sure it is safe for you, tell your doctor if you have:liver or kidney disease;

• heart disease;


• a bleeding or blood clotting disorder;


• seizures or epilepsy;


• bipolar disorder (manic depression);


• a history of Long QT syndrome;


• a history of drug abuse or suicidal thoughts;


• if you are being treated with methylene blue injection; or


• if you have recently had a heart attack.

Side effects:Call your doctor at once if you have:

• very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;


• agitation, hallucinations, overactive reflexes, nausea, diarrhea, loss of coordination;


• headache with chest pain and severe dizziness, fainting;


• slurred speech, vomiting, severe weakness, muscle cramps, feeling unsteady, seizure (convulsions), shallow breathing (breathing may stop); or


• chest pain or pressure, tight feeling in your neck or jaw, sweating, pain spreading to your arm or shoulder.

Common side effects may include:

• drowsiness, dizziness, memory problems


• mild headache, tired feeling;


• stomach pain, constipation;


• dry mouth, altered sense of taste;


• back pain; or


• blurred vision.

Drug interaction:

• antifungal medication-itraconazole, ketoconazole, posaconazole, voriconazole;


• anti-malaria medication-artemether and lumefantrine, chloroquine, halofantrine, mefloquine;


• a blood thinner such as warfarin, Coumadin;


• heart rhythm medicine-amiodarone, digoxin, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, nicardipine, procainamide, propafenone, quinidine, sotalol;


• hepatitis C medications-boceprevir, telaprevir;


• HIV/AIDS medication-atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;


• medicine to prevent or treat nausea and vomiting-dolasetron, droperidol, ondansetron;


• medicine to treat a psychiatric disorder-chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, thioridazine, ziprasidone;


• migraine headache medicine-sumatriptan, zolmitriptan;

Storage:Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.